Electrostatic control of aromatic stacking interactions

被引：281

作者：

Cockroft, SL

Hunter, CA ^{[1
]}

Lawson, KR

Perkins, J

Urch, CJ

机构：

[1] Univ Sheffield, Krebs Inst Biomolec Res, Dept Chem, Ctr Chem Biol, Sheffield S3 7HF, S Yorkshire, England

[2] Jealotts Hill Int Res Ctr, Syngenta, Bracknell RG42 6EY, Berks, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 24期

关键词：

D O I：

10.1021/ja050880n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A supramolecular approach has been used to investigate the free energies of intermolecular aromatic stacking interactions. Chemical double mutant cycles have been used to measure the effect of a range of substituents on face-to-face stacking interactions with phenyl and pentafluorophenyl rings. Electrostatic effects dominate the trends in interaction energy. Copyright © 2005 American Chemical Society.

引用

页码：8594 / 8595

页数：2

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