Circadian variation of the cell proliferation in the jejunal epithelium of rats at weaning phase

被引：7

作者：

Gomes, JR ^{[1
]}

Pereira, AAM ^{[1
]}

Barth, L ^{[1
]}

Silva, JS ^{[1
]}

Leite, ML ^{[1
]}

Wille, ACM ^{[1
]}

Soares, MAM ^{[1
]}

机构：

[1] Univ Estadual Ponta Grossa, Dept Biol Estrut Mol & Genet, BR-84030900 Ponta Grossa, Parana, Brazil

来源：

CELL PROLIFERATION | 2005年 / 38卷 / 03期

关键词：

D O I：

10.1111/j.1365-2184.2005.00339.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Circadian variation in cell proliferation of the jejunal epithelium of 18-day-old rats was studied using the 2-h arrested metaphase score and crypt isolation method. A continuous decrease in the arrested metaphases occurred from 07.00 h to13.00 h. From 17.00 h arrested metaphase values increased and were maintained at the higher level during the dark period as showed by Cosinor analyses (P < 0.05). These results indicate that in the young rat there is already a circadian variation in jejunal epithelial cell proliferation as early as 18 days. We can even suggest that the presence of a circadian rhythm at weaning contributes to the steady state of cell proliferation in the intestinal epithelium observed in adult life.

引用

页码：147 / 152

页数：6

共 24 条

[1] STUDIES ON MECHANISM OF DIURNAL-VARIATION OF PROLIFERATIVE INDEXES IN SMALL BOWEL MUCOSA OF RAT [J].