Role of arachidonic acid metabolism in thymocyte apoptosis after irradiation

被引：34

作者：

Korystov, YN

Dobrovinskaya, OR

Shaposhnikova, VV

Eidus, LK

机构：

[1] Laboratory of Cell Radiobiology, Inst. of Theor. and Exp. Biophysics, Russian Academy of Sciences

来源：

FEBS LETTERS | 1996年 / 388卷 / 2-3期

关键词：

irradiation; thymocyte apoptosis; arachidonic acid metabolism;

D O I：

10.1016/0014-5793(96)00538-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study demonstrates that DNA fragmentation, nuclear pycnosis and trypan blue staining of irradiated thymocytes is prevented by inhibition of the lipoxygenase pathway of arachidonic acid metabolism and is not affected by cyclooxygenase inhibition, Exposed to irradiation [H-3]arachidonic acid-labeled thymocytes release radioactive products to the external medium, The process is blocked by the lipoxygenase inhibitor, nordihydroguaiaretic acid. Thus, it can be concluded that irradiation activates arachidonic acid metabolism and that lipoxygenase metabolites play an important role in thymocyte apoptosis.

引用

页码：238 / 241

页数：4

共 31 条

[1]

ARENDS MJ, 1991, INT REV EXP PATHOL, V32, P223

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