Auto-tandem catalysis:: Synthesis of substituted 11H-indolo [3,2-c]quinolines via palladium-catalyzed intermolecular C-N and intramolecular C-C bond formation

被引：62

作者：

Meyers, Caroline ^{[1
]}

Rornbouts, Geert ^{[1
]}

Loones, Kristof T. J. ^{[1
]}

Coelho, Alberto ^{[1
]}

Maes, Bert U. W. ^{[1
]}

机构：

[1] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 03期

关键词：

amination; C-H activation; malaria; palladium; tandem catalysis;

D O I：

10.1002/adsc.200700328

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

D-Ring substituted 11H-indolo[3,2-c]quinolines (4) have been prepared via auto-tandem consecutive intermolecular Buchwald-Hartwig reaction and intramolecular palladium-catalyzed arylation on 4-chloroquinoline (1) with N-unsubstituted 2-chloroanilines (2). The reported 11H-indolo[3,2-c]quinolines (4) represent the first examples in which tandem catalysis has been used to construct N-unsubstituted carbolines.

引用

收藏

页码：465 / 470

页数：6

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