Prognostic value of treadmill exercise testing - A population-based study in Olmsted County, Minnesota

被引:122
作者
Roger, VL
Jacobsen, SJ
Pellikka, PA
Miller, TD
Bailey, KR
Gersh, BJ
机构
[1] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Clin Epidemiol Sect, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA
[4] Georgetown Univ, Med Ctr, Div Cardiol, Washington, DC 20007 USA
关键词
exercise; women; epidemiology;
D O I
10.1161/01.CIR.98.25.2836
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-The prognostic value of treadmill exercise testing (TMET) has been studied in selected populations. The generalizability of these data to different populations and to women is uncertain. Methods and Results-A retrospective, population-based cohort study of all persons (1452 men and 741 women) who underwent TMET in years 1987 to 1989 in Olmsted County, Minnesota, was undertaken. Individuals were followed up for all-cause mortality and cardiac events (cardiac deaths, nonfatal myocardial infarction, or congestive heart failure). Sex-specific analyses were performed to determine whether the predictors of outcome and the magnitude of the associations were similar in both sexes. In men, 77 deaths and 106 cardiac events occurred during 8956 person-years of observation; in women, 46 deaths and 54 cardiac events occurred during 4801 person-years of follow-up. Exercise-induced angina, ECG changes, and workload achieved on the TMET were strongly associated with all-cause mortality and cardiac events in both sexes, and the strength of the association was similar. After adjustment, workload was the only TMET variable associated with outcome. A higher workload was associated with a reduction in the risk of cardiac events and of all-cause mortality; the protective effect of exercise capacity was strong and was similar in both sexes. Conclusions-In this population-based cohort, exercise capacity was the TMET variable that exhibited the strongest association with all-cause mortality and cardiac events. This protective effect of exercise capacity was observed in both sexes.
引用
收藏
页码:2836 / 2841
页数:6
相关论文
共 34 条
[1]  
*AM COLL SPORTS ME, 1991, GUID EX TEST PRESCR
[2]  
[Anonymous], PRIM PREV CARD
[3]   A METAANALYSIS OF PHYSICAL-ACTIVITY IN THE PREVENTION OF CORONARY HEART-DISEASE [J].
BERLIN, JA ;
COLDITZ, GA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 132 (04) :612-628
[4]   Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women [J].
Blair, SN ;
Kampert, JB ;
Kohl, HW ;
Barlow, CE ;
Macera, CA ;
Paffenbarger, RS ;
Gibbons, LW .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (03) :205-210
[5]   VALUE OF MAXIMAL EXERCISE TESTS IN RISK ASSESSMENT OF PRIMARY CORONARY HEART-DISEASE EVENTS IN HEALTHY-MEN - 5 YEARS EXPERIENCE OF THE SEATTLE HEART WATCH STUDY [J].
BRUCE, RA ;
DEROUEN, TA ;
HOSSACK, KF .
AMERICAN JOURNAL OF CARDIOLOGY, 1980, 46 (03) :371-378
[6]   ENHANCED RISK ASSESSMENT FOR PRIMARY CORONARY HEART-DISEASE EVENTS BY MAXIMAL EXERCISE TESTING - 10 YEARS EXPERIENCE OF SEATTLE HEART WATCH [J].
BRUCE, RA ;
HOSSACK, KF ;
DEROUEN, TA ;
HOFER, V .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1983, 2 (03) :565-573
[7]   A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].
CHARLSON, ME ;
POMPEI, P ;
ALES, KL ;
MACKENZIE, CR .
JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383
[8]   SURVIVAL OF PATIENTS WITH A STRONGLY POSITIVE EXERCISE ELECTROCARDIOGRAM [J].
DAGENAIS, GR ;
ROULEAU, JR ;
CHRISTEN, A ;
FABIA, J .
CIRCULATION, 1982, 65 (03) :452-456
[9]   PREDICTIVE IMPLICATIONS OF STRESS TESTING - FOLLOW-UP OF 2700 SUBJECTS AFTER MAXIMUM TREADMILL STRESS TESTING [J].
ELLESTAD, MH ;
WAN, MKC .
CIRCULATION, 1975, 51 (02) :363-369
[10]   PREVALENCE AND PROGNOSTIC-SIGNIFICANCE OF EXERCISE-INDUCED SILENT MYOCARDIAL ISCHEMIA DETECTED BY THALLIUM SCINTIGRAPHY AND ELECTROCARDIOGRAPHY IN ASYMPTOMATIC VOLUNTEERS [J].
FLEG, JL ;
GERSTENBLITH, G ;
ZONDERMAN, AB ;
BECKER, LC ;
WEISFELDT, ML ;
COSTA, PT ;
LAKATTA, EG .
CIRCULATION, 1990, 81 (02) :428-436