Risk of cancer in BRCA1 and BRCA2 mutation-positive and -negative breast cancer families (Finland)

被引:21
作者
Eerola, H
Pukkala, E
Pyrhönen, S
Blomqvist, C
Sankila, R
Nevanlinna, H
机构
[1] Univ Helsinki, Cent Hosp, Dept Oncol, Helsinki, Finland
[2] Univ Helsinki, Cent Hosp, Dept Obstet & Gynaecol, Helsinki, Finland
[3] Finnish Canc Registry, Inst Stat & Epidemiol Canc Res, FIN-00170 Helsinki, Finland
[4] Turku Univ Hosp, Dept Radiotherapy & Oncol, FIN-20520 Turku, Finland
[5] Univ Uppsala Hosp, Dept Oncol, S-75185 Uppsala, Sweden
[6] Int Agcy Res Canc, F-69372 Lyon, France
关键词
BRCA1; BRCA2; breast neoplasms; familial; risk;
D O I
10.1023/A:1011272919982
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives: To compare the risk of cancer between BRCA1 or BRCA2 mutation-positive and -negative families. Methods: We assessed standardized incidence ratios (SIR) in 107 Finnish breast cancer families (12 BRCA1, 11 BRCA2, 84 non-BRCA1/2) with confirmed genealogy. The observed numbers of cancer cases were compared to the expected ones; both numbers were based on the population-based Finnish Cancer Registry. Results: Risk of ovarian cancer for first-degree relatives was high in BRCA1 (SIR 29, 95% confidence interval 9.4-68) and in BRCA2 families (SIR 18, 8.3-35), but not increased for non-BRCA1/2 families (SIR 1.0, 0.2-2.9). The SIR for subsequent ovarian cancer among breast cancer patients was 61 (20-142), 38 (11-98), and 0 (0-4.2), respectively. The risk of subsequent new breast cancer among breast cancer patients was equally high in BRCA1 families (SIR 11, 3.6-26) and in BRCA2 families (SIR 10, 3.3-24) and somewhat lower in mutation-negative families (SIR 3.7, 2.1-6.1). The risk of breast cancer among relatives was markedly increased in all three groups. The only elevated SIR, besides breast and ovarian, was that for prostate cancer in BRCA2 families (SIR 4.9, 1.8-11). Conclusions: The excess risk of breast cancer in non-BRCA1/2 families suggests the existence of another predisposition gene which seems not to be linked with increased risk of ovarian cancer.
引用
收藏
页码:739 / 746
页数:8
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