Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy

被引：10

作者：

Cavallaro, Gennara ^{[1
]}

Pitarresi, Giovanna ^{[1
]}

Giammona, Gaetano ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Chim & Tecnol Farmaceut, I-90123 Palermo, Italy

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 18期

关键词：

a alpha; beta-poly(N-2-hydroxyethyl)-DL-aspartamide; alpha; beta-polyaspartylhydrazide; poly(glutamic acid); carriers; anticancer drugs; MOLECULAR CHARACTERIZATION; POLYMERS; ALPHA; BETA-POLYASPARTHYDRAZIDE; COPOLYMERS; SYSTEMS; PHEA;

D O I：

10.2174/156802611797183276

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

In the last twenty years a depth study on potential pharmaceutical applications of synthetic polymers at protein-like structure as carrier for macromolecular prodrug production has been performed in academia and in industry. In particular, alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), alpha,beta-polyaspartylhydrazide (PAHy), poly(glutamic acid) (PGA), poly(aspartic acid) (PAA) and polylysine (PLL) have been extensively studied in this field. In the present review, the use of PHEA, PAHy, PGA as starting materials to prepare macromolecular prodrugs is reported and drug delivery and targeting aspects have been considered.

引用

收藏

页码：2382 / 2389

页数：8

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