Mannose-binding plant lectins:: Different structural scaffolds for a common sugar-recognition process

被引:142
作者
Barre, A
Bourne, Y
Van Damme, EJM
Peumans, WJ
Rougé, P
机构
[1] Inst Pharmacol & Biol Struct, CNRS, UMR 5089, F-31077 Toulouse 4, France
[2] AFMB, CNRS, UMR 31, F-13402 Marseille, France
[3] Katholieke Univ Leuven, Lab Phytopathol & Plant Protect, B-3001 Louvain, Belgium
关键词
mannose-binding lectins; structural organization; binding-specificity;
D O I
10.1016/S0300-9084(01)01315-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mannose-specific lectins are widely distributed in higher plants and are believed to play a role in recognition of high-mannose type glycans of foreign micro-organisms or plant predators. Structural studies have demonstrated that the mannose-binding specificity of lectins is mediated by distinct structural scaffolds, The mannose/glucose-specific legume (e.g., Con A, pea lectin) exhibit the canonical twelve-stranded beta -sandwich structure. In contrast to legume lectins that interact with both mannose and glucose, the monocot mannose-binding lectins (e.g., the Galanthus nivalis agglutinin or GNA from bulbs) react exclusively with mannose and mannose-containing N-glycans. These lectins possess a beta -prism structure. More recently, an increasing number of mannose-specific lectins structurally related to jacalin (e.g., the lectins from the Jerusalem artichoke, banana or rice), which also exhibit a beta -prism organization, were characterized. Jacalin itself was re-defined as a polyspecific lectin which, in addition to galactose, also interacts with mannose and mannose-containing glycans. Finally the B-chain of the type II RIP of iris, which has the same beta -prism structure as all other members of the ricin-B family, interacts specifically with mannose and galactose. This structural diversity associated with the specific recognition of high-mannose type glycans highlights the importance of mannose-specific lectins as recognition molecules in higher plants. (C) 2001 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:645 / 651
页数:7
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