Bioactive compounds from Iostephane heterophylla (Asteraceae)

被引：21

作者：

Aguilar, MI

Delgado, G

Hernández, MD

Villarreal, ML

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farmacia Conjunto E, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[3] Inst Politecn Nacl Prolongac Carpio & Plan Ayala, Escuela Nacl Ciencias Biol, Dept Farmacia, Mexico City, DF, Mexico

[4] IMSS, Ctr Invest Biomed Sur, Xochitepec, Morelos, Mexico

来源：

NATURAL PRODUCT LETTERS | 2001年 / 15卷 / 02期

关键词：

Iostephane heterophylla; Asteraceae; bisabolene sesquiterpenoids; bisabolene glycoside; bioactive compounds;

D O I：

10.1080/10575630108041265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The novel bisabolene sesquiterpenes 3-6, were isolated from Iostephane heterophylla, using bioguided fractionation The new compounds were determined to be (12R/12S)-12,13-epoxy-xanthorrhizols (3,4) and (12R/12S)-12,13-dihydro-12,13-dihydroxy-xanthorrizols (5,6) and their structures were characterized by analysis of spectroscopic data and by chemical correlation from xanthorrhizol (2). The stereochemistry at C-12 of 5 was deduced using the modified Mosher experiment. Some of the isolated compounds elicited activity against gram positive and gram negative bacteria, levadura and dermatophytes.

引用

页码：93 / 101

页数：9

共 13 条

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