Timeline - The history of cancer epigenetics

被引：1606

作者：

Feinberg, AP ^{[1
]}

Tycko, B

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[4] Columbia Univ Coll Phys & Surg, Inst Canc Genet, New York, NY 10032 USA

[5] Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrc1279

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of human cancer genetics. But this area has become increasingly visible with a growing understanding of specific epigenetic mechanisms and their role in cancer, including hypomethylation, hypermethylation, loss of imprinting and chromatin modification. This timeline traces the field from its conception to the present day. It also addresses the genetic basis of epigenetic changes - an emerging area that promises to unite cancer genetics and epigenetics, and might serve as a model for understanding the epigenetic basis of human disease more generally.

引用

页码：143 / 153

页数：11

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