The effects of Azone and capsaicin on the permeation of naproxen through human skin

被引：43

作者：

Degim, IT

Uslu, A

Hadgraft, J

Atay, T

Akay, C

Cevheroglu, S

机构：

[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

[2] Gazi Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06330 Ankara, Turkey

[3] Turkish Army Drug Factory, TR-061000 Ankara, Turkey

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 179卷 / 01期

关键词：

Azone; capsaicin; naproxen; penetration enhancers; skin absorption;

D O I：

10.1016/S0378-5173(98)00353-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The permeation of naproxen through excised human skin and isolated perfused rabbit ear skin has been determined. It was found that both Atone and capsaicin enhanced the permeation with an enhancement ratio of up to 4-fold. The magnitudes of the effect were similar in human and rabbit skin. The permeation of naproxen from a saturated solution of the drug through skin pre-treated with Atone was similar to that from a commercial preparation (Naprosyn). In the perfused rabbit ear experiments the presence of capsaicin had no effect on the vasodilatation of the blood vessels, inferring that the penetration enhancement was a direct result of capsaicin influencing the barrier function of the skin. Structural similarities between Atone and capsaicin were seen using molecular graphics. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：21 / 25

页数：5

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