miRNA Processing and Human Cancer: DICER1 Cuts the Mustard

被引：58

作者：

Bahubeshi, Amin ^{[1
,2
,3
,4
]}

Tischkowitz, Marc ^{[1
,2
,3
,4
]}

Foulkes, William D. ^{[1
,2
,3
,4
,5
]}

机构：

[1] McGill Univ, Program Canc Genet, Dept Oncol, Montreal, PQ H2W 1S6, Canada

[2] McGill Univ, Program Canc Genet, Dept Human Genet, Montreal, PQ H2W 1S6, Canada

[3] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[4] McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada

[5] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ H3G 1A4, Canada

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 111期

关键词：

MICRORNA EXPRESSION; CELL-PROLIFERATION; GENETIC-VARIATIONS; DOWN-REGULATION; OVARIAN-CANCER; BREAST-CANCER; MUTATIONS; DROSHA; CARCINOMA; RISK;

D O I：

10.1126/scitranslmed.3002493

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Numerous studies have implicated microRNAs (miRNAs) in cancer initiation and progression. In contrast, only recently has attention been focused on the pathway that generates these regulatory molecules. The identication of neoplasia-associated germline mutations in DICER1 has focused translational research on components of the miRNA processing pathway. Deciphering of the many links between miRNA processing perturbations and cancer will likely provide insights into mechanisms of cancer control.

引用

收藏

页数：6

相关论文

共 48 条

[1] Germline DICER1 mutations and familial cystic nephroma [J].

Bahubeshi, Amin ;

Bal, Nebil ;

Frio, Thomas Rio ;

Hamel, Nancy ;

Pouchet, Carly ;

Yilmaz, Ahmet ;

Soglio, Dorothee Bouron-Dal ;

Williams, Gretchen M. ;

Tischkowitz, Marc ;

Priest, John R. ;

Foulkes, William D. .

JOURNAL OF MEDICAL GENETICS, 2010, 47 (12) :863-866

[2] Familial nontoxic multinodular thyroid goiter locus maps to chromosome 149 but does not account for familial nonmedullary thyroid cancer [J].

Bignell, GR ;

Canzian, F ;

Shayeghi, M ;

Stark, M ;

Shugart, YY ;

Biggs, P ;

Mangion, J ;

Hamoudi, R ;

Rosenblatt, J ;

Buu, P ;

Sun, S ;

Stoffer, SS ;

Goldgar, DE ;

Romeo, G ;

Houlston, RS ;

Narod, SA ;

Stratton, MR ;

Foulkes, WD .

AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (05) :1123-1130

[3] MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype [J].

Blenkiron, Cherie ;

Goldstein, Leonard D. ;

Thorne, Natalie P. ;

Spiteri, Inmaculada ;

Chin, Suet-Feung ;

Dunning, Mark J. ;

Barbosa-Morais, Nuno L. ;

Teschendorff, Andrew E. ;

Green, Andrew R. ;

Ellis, Ian O. ;

Tavare, Simon ;

Caldas, Carlos ;

Miska, Eric A. .

GENOME BIOLOGY, 2007, 8 (10)

[4] let-7 microRNAs in development, stem cells and cancer [J].

Buessing, Ingo ;

Slack, Frank J. ;

Grosshans, Helge .

TRENDS IN MOLECULAR MEDICINE, 2008, 14 (09) :400-409

[5] Distinct MicroRNA Alterations Characterize High- and Low-Grade Bladder Cancer [J].

Catto, James W. F. ;

Miah, Saiful ;

Owen, Helen C. ;

Bryant, Helen ;

Myers, Katie ;

Dudziec, Ewa ;

Larre, Stephane ;

Milo, Marta ;

Rehman, Ishtiaq ;

Rosario, Derek J. ;

Di Martino, Erica ;

Knowles, Margaret A. ;

Meuth, Mark ;

Harris, Adrian L. ;

Hamdy, Freddie C. .

CANCER RESEARCH, 2009, 69 (21) :8472-8481

[6] A Dicer-independent miRNA biogenesis pathway that requires Ago catalysis [J].

Cheloufi, Sihem ;

Dos Santos, Camila O. ;

Chong, Mark M. W. ;

Hannon, Gregory J. .

NATURE, 2010, 465 (7298) :584-U76

[7] Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of dicer expression [J].

Chiosea, S. I. ;

Barnes, E. L. ;

Lai, S. Y. ;

Egloff, A. M. ;

Sargent, R. L. ;

Hunt, J. L. ;

Seethala, R. R. .

VIRCHOWS ARCHIV, 2008, 452 (06) :629-635

[8] Overexpression of Dicer in precursor lesions of lung adenocarcinoma [J].

Chiosea, Simion ;

Jelezcova, Elena ;

Chandran, Uma ;

Luo, Jianhua ;

Mantha, Geeta ;

Sobol, Robert W. ;

Dacic, Sanja .

CANCER RESEARCH, 2007, 67 (05) :2345-2350

[9] Up-regulation of dicer, a component of the microRNA machinery, in prostate adenocarcinoma [J].

Chiosea, Simion ;

Jelezcova, Elena ;

Chandran, Uma ;

Acquafondata, Marie ;

McHale, Teresa ;

Sobol, Robert W. ;

Dhir, Rajiv .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 169 (05) :1812-1820

[10] A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity [J].

Cifuentes, Daniel ;

Xue, Huiling ;

Taylor, David W. ;

Patnode, Heather ;

Mishima, Yuichiro ;

Cheloufi, Sihem ;

Ma, Enbo ;

Mane, Shrikant ;

Hannon, Gregory J. ;

Lawson, Nathan D. ;

Wolfe, Scot A. ;

Giraldez, Antonio J. .

SCIENCE, 2010, 328 (5986) :1694-1698

← 1 2 3 4 5 →