Controlled, single-step, stratum corneum disruption as a pretreatment for immunization via a patch

被引：46

作者：

Frerichs, David M. ^{[1
]}

Ellingsworth, Larry R. ^{[1
]}

Frech, Sarah A. ^{[1
]}

Flyer, David C. ^{[1
]}

Villar, Christina P. ^{[1
]}

Yu, Jianmei ^{[1
]}

Glenn, Gregory M. ^{[1
]}

机构：

[1] Iomai Corp, Gaithersburg, MD 20878 USA

来源：

VACCINE | 2008年 / 26卷 / 22期

关键词：

transcutaneous immunization; skin pretreatment; LT;

D O I：

10.1016/j.vaccine.2008.02.070

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A Skin Prep System (SPS) has been developed to provide a well-tolerated and controlled method of stratum corneum disruption using mild abrasion as part of transcutaneous immunization (TCI). In this study, four groups (n = 10) of volunteers were pretreated with the SPS using three different lengths of mild abrasive strips (13 mm, 25 mm and 38 mm), or a handheld applicator. They then received a vaccine patch containing 50 jig of the heat-labile enterotoxin from Escherichia coli (LT) at day 0 and day 21. Subsequent anti-LT IgG antibody responses were dependent on abrasive strip length, with highest immune responses seen after use of the longest strip. The development of a simple, single-use, disposable device that is well-tolerated and allows disruption to be modulated represents an important step forward in physical penetration enhancement for the skin. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2782 / 2787

页数：6

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