In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

被引：65

作者：

Akova, M ^{[1
]}

Gür, D ^{[1
]}

Livermore, DM ^{[1
]}

Kocagöz, T ^{[1
]}

Akalin, HE ^{[1
]}

机构：

[1] Univ Hacettepe, Sch Med, Dept Med, Infect Dis Sect, TR-06100 Ankara, Turkey

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 05期

关键词：

D O I：

10.1128/AAC.43.5.1298

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxcycline and rifampin-doxycycline combinations.

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页码：1298 / 1300

页数：3

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