Modulation of propagation from an ectopic focus by electrical load and by extracellular potassium

被引:24
作者
Wagner, MB
Golod, D
Wilders, R
Verheijck, EE
Joyner, RW
Kumar, R
Jongsma, HJ
vanGinneken, ACG
Goolsby, WN
机构
[1] EMORY UNIV, DEPT PEDIAT, CHILDRENS HEART CTR, TODD FRANKLIN CARDIAC RES LAB, ATLANTA, GA 30322 USA
[2] UNIV UTRECHT, DEPT MED PHYSIOL & SPORTS MED, NL-3584 CG UTRECHT, NETHERLANDS
[3] UNIV AMSTERDAM, DEPT PHYSIOL, NL-1105 AZ AMSTERDAM, NETHERLANDS
[4] UNIV CALIF SAN FRANCISCO, BIOENGN GRAD GRP, SAN FRANCISCO, CA 94143 USA
[5] UNIV CALIF BERKELEY, BERKELEY, CA 94720 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1997年 / 272卷 / 04期
关键词
arrhythmia; action potential; rabbits; computer model;
D O I
10.1152/ajpheart.1997.272.4.H1759
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We previously developed a technique (R. Kumar, R. Wilders, R. W. Joyner, H. J. Jongsma, E. E. Verheijck, D. A. Golod, A. C. G. van Ginneken, and W. N. Goolsby. Circulation 94: 833-841, 1996) for study of a mathematical model cell with spontaneous activity, viz. a ''realtime'' simulation of a rabbit sinoatrial node cell (SAN model cell; R. Wilders, H. J. Jongsma, and A. C. van Ginneken. Biophys. J. 60: 1202-1216, 1991) simultaneously being electrically coupled via our ''coupling clamp'' [H. Sugiura and R. W. Joyner. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1591-H1604, 1992] circuit to a real, isolated ventricular myocyte. We now apply this technique to investigate effects of coupling conductance (G(c)), cell size, and the modulation of membrane potential by elevated extracellular potassium concentration on the ability of an ectopic focus, represented by the SAN model cell, to successfully drive a ventricular cell. Values of G(c) and the relative sizes of the two cells define three possible outcomes: 1) spontaneous pacing of the SAN model cell but not driving of the ventricular cell, 2) cessation of spontaneous pacing, or 3) pacing of the SAN model cell and driving of the ventricular cell. Below a critical size of the SAN model cell only the first two of these outcomes is possible. Above this critical size there is a range of G(c) that allows successful operation of the system as an ectopic focus. Elevation of extracellular potassium concentration from 4 to 8 mM increases both the lower bound and upper bound of G(c) for this range. Elevation of extracellular potassium concentration, as commonly observed in myocardial ischemia, may have effects on either inhibiting or releasing from inhibition an ectopic focus.
引用
收藏
页码:H1759 / H1769
页数:11
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