GRAsPing unconventional secretion

被引：18

作者：

Levi, Stephanie K. ^{[1
]}

Glick, Benjamin S. ^{[1
]}

机构：

[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

来源：

CELL | 2007年 / 130卷 / 03期

关键词：

D O I：

10.1016/j.cell.2007.07.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GRASP proteins associate with the Golgi apparatus and have been implicated in the stacking of Golgi cisternae, vesicle tethering, and mitotic progression, but their specific functions are unclear. In this issue, Kinseth et al. ( 2007) show unexpectedly that a GRASP homolog is required for an unconventional secretory pathway that bypasses the usual route for Golgi-dependent membrane traffic.

引用

页码：407 / 409

页数：4

共 10 条

[1] Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus [J].

Barr, FA ;

Preisinger, C ;

Kopajtich, R ;

Körner, R .

JOURNAL OF CELL BIOLOGY, 2001, 155 (06) :885-891

[2] The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic [J].

Behnia, Rudy ;

Barr, Francis A. ;

Flanagan, John J. ;

Barlowe, Charles ;

Munro, Sean .

JOURNAL OF CELL BIOLOGY, 2007, 176 (03) :255-261

[3] Mitogen-activated protein kinase kinase 1-dependent Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition [J].

Feinstein, Timothy N. ;

Linstedt, Adam D. .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (02) :594-604

[4]

KINSETH MA, 2007, IN PRESS CELL

[5] dGRASP localization and function in the early exocytic pathway in Drosophila S2 cells [J].

Kondylis, V ;

Spoorendonk, KM ;

Rabouille, C .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (09) :4061-4072

[6] Inheritance and biogenesis of organelles in the secretory pathway [J].

Lowe, Martin ;

Barr, Francis A. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (06) :429-439

[7] Unconventional secretory routes: Direct protein export across the plasma membrane of mammalian cells [J].

Nickel, W .

TRAFFIC, 2005, 6 (08) :607-614

[8] GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution [J].

Puthenveedu, MA ;

Bachert, C ;

Puri, S ;

Lanni, F ;

Linstedt, AD .

NATURE CELL BIOLOGY, 2006, 8 (03) :238-248

[9] The Golgi-associated protein GRASP65 regulates spindle dynamics and is essential for cell division [J].

Sütterlin, C ;

Polishchuk, R ;

Pecot, M ;

Malhotra, V .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (07) :3211-3222

[10] A direct role for GRASP65 as a mitotically regulated Golgi stacking factor [J].

Wang, YZ ;

Seemann, J ;

Pypaert, M ;

Shorter, J ;

Warren, G .

EMBO JOURNAL, 2003, 22 (13) :3279-3290

← 1 →