A second canon:: Functions and mechanisms of β-catenin-independent wnt signaling

被引：1112

作者：

Veeman, MT

Axelrod, JD

Moon, RT ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Mol & Cellular Biol Program, Seattle, WA 98195 USA

[3] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 5卷 / 03期

基金：

美国国家卫生研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S1534-5807(03)00266-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

More is becoming known about so-called noncanonical Wnt pathways that signal independently of beta-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling. We also discuss some unresolved and vexing questions. How many noncanonical Wnt pathways are there? How extensive are the parallels between Drosophila planar polarization and vertebrate convergence and extension? Last, we will outline some challenges and difficulties we foresee for this exciting but still very young field.

引用

页码：367 / 377

页数：11

共 94 条

[1] Planar signaling and morphogenesis in Drosophila
Adler, PN
[J]. DEVELOPMENTAL CELL, 2002, 2 (05) : 525 - 535
[2] Frizzled signaling and cell-cell interactions in planar polarity
Adler, PN
Lee, H
[J]. CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (05) : 635 - 640
[3] Wnt signalling regulates myogenic differentiation in the developing avian wing
Anakwe, K
Robson, L
Hadley, J
Buxton, P
Church, V
Allen, S
Hartmann, C
Harfe, B
Nohno, T
Brown, AMC
Evans, DJR
Francis-West, P
[J]. DEVELOPMENT, 2003, 130 (15): : 3503 - 3514
[4] Axelrod JD, 2001, GENE DEV, V15, P1182
[5] Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
Axelrod, JD
Miller, JR
Shulman, JM
Moon, RT
Perrimon, N
[J]. GENES & DEVELOPMENT, 1998, 12 (16) : 2610 - 2622
[6] Axelrod Jeffrey D, 2002, ScientificWorldJournal, V2, P434
[7] Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning
Bastock, R
Strutt, H
Strutt, D
[J]. DEVELOPMENT, 2003, 130 (13): : 3007 - 3014
[8] Bhanot P, 1999, DEVELOPMENT, V126, P4175
[9] Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
Bilder, D
Perrimon, N
[J]. NATURE, 2000, 403 (6770) : 676 - 680
[10] Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
Boutros, M
Paricio, N
Strutt, DI
Mlodzik, M
[J]. CELL, 1998, 94 (01) : 109 - 118

← 1 2 3 4 5 6 7 8 9 10 →