Alternative transcription factor σB is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate

被引:192
作者
Rachid, S
Ohlsen, K
Wallner, U
Hacker, J
Hecker, M
Ziebuhr, W
机构
[1] Inst Mol Infekt Biol, D-97070 Wurzburg, Germany
[2] Inst Mikrobiol & Mol Biol, D-17487 Greifswald, Germany
关键词
D O I
10.1128/JB.182.23.6824-6826.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma (B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma (B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma (B) in S. aureus biofilm regulation under environmental stress conditions.
引用
收藏
页码:6824 / 6826
页数:3
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