An Achilles' heel for breast cancer?

被引：4

作者：

Caldecott, KW ^{[1
]}

Chalmers, A ^{[1
]}

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2005年 / 12卷 / 05期

关键词：

D O I：

10.1038/nsmb0505-387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two recent reports describe potentially novel therapeutic approaches for treating tumors arising from mutations in the tumor suppressor genes BRCA1 and BRCA2. These studies support the idea that selective killing of tumor cells can be achieved by targeting a specific DNA repair pathway on which an individual tumor type has become dependent.

引用

页码：387 / 388

页数：2

共 16 条

[1] The PARP superfamily [J].

Amé, JC ;

Spenlehauer, C ;

de Murcia, G .

BIOESSAYS, 2004, 26 (08) :882-893

[2] Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase [J].

Bryant, HE ;

Schultz, N ;

Thomas, HD ;

Parker, KM ;

Flower, D ;

Lopez, E ;

Kyle, S ;

Meuth, M ;

Curtin, NJ ;

Helleday, T .

NATURE, 2005, 434 (7035) :913-917

[3] XRCC1 and DNA strand break repair [J].

Caldecott, KW .

DNA REPAIR, 2003, 2 (09) :955-969

[4] Improved survival in women with BRCA-associated ovarian carcinoma [J].

Cass, I ;

Baldwin, RL ;

Varkey, T ;

Moslehi, R ;

Narod, SA ;

Karlan, BY .

CANCER, 2003, 97 (09) :2187-2195

[5] A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage [J].

El-Khamisy, SF ;

Masutani, M ;

Suzuki, H ;

Caldecott, KW .

NUCLEIC ACIDS RESEARCH, 2003, 31 (19) :5526-5533

[6] Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 [J].

El-Khamisy, SF ;

Saifi, GM ;

Weinfeld, M ;

Johansson, F ;

Helleday, T ;

Lupski, JR ;

Caldecott, KW .

NATURE, 2005, 434 (7029) :108-113

[7]

Emens LA, 2004, ONCOLOGY-NY, V18, P1117

[8] Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy [J].

Farmer, H ;

McCabe, N ;

Lord, CJ ;

Tutt, ANJ ;

Johnson, DA ;

Richardson, TB ;

Santarosa, M ;

Dillon, KJ ;

Hickson, I ;

Knights, C ;

Martin, NMB ;

Jackson, SP ;

Smith, GCM ;

Ashworth, A .

NATURE, 2005, 434 (7035) :917-921

[9] Single-strand interruptions in replicating chromosomes cause double-strand breaks [J].

Kuzminov, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8241-8246

[10] The pathology of familial breast cancer:: Predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2 [J].

Lakhani, SR ;

van de Vijver, MJ ;

Jacquemier, J ;

Anderson, TJ ;

Osin, PP ;

McGuffog, L ;

Easton, DF .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (09) :2310-2318

← 1 2 →