Random research

被引：16

作者：

Moyé, LA ^{[1
]}

机构：

[1] Univ Texas, Sch Publ Hlth, Houston, TX 77030 USA

来源：

CIRCULATION | 2001年 / 103卷 / 25期

关键词：

trials; statistics; population; epidemiology;

D O I：

10.1161/hc2501.090955

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Advances in computing have combined with the rapid dissemination of treatment discoveries for diseases of public health importance to create pressure for accelerated promulgation of promising research results to the medical community. The 2 recent examples of the US Carvedilol Heart Failure program and the Evaluation of Losartan In the Elderly (ELITE) study demonstrate the importance of the prospective nature of research design, as well as the consequences of its abandonment. This article explains in nonmathematical terms the rationale for the tenet "first say what you will do, then do what you said" in sample-based research.

引用

页码：3150 / 3153

页数：4

共 18 条

[1] D'Agostino RB, 2000, STAT MED, V19, P763, DOI 10.1002/(SICI)1097-0258(20000330)19:6<763::AID-SIM517>3.0.CO
[2] 2-8
[3] Carvedilol and the food and drug administration (FDA) approval process: The FDA paradigm and reflections on hypothesis testing
Fisher, LD
[J]. CONTROLLED CLINICAL TRIALS, 1999, 20 (01): : 16 - 39
[4] FRIEDMAN L, 1996, FUNDAMENTALS CLIN TR, P307
[5] Koch GG, 2000, STAT MED, V19, P781, DOI 10.1002/(SICI)1097-0258(20000330)19:6<781::AID-SIM519>3.3.CO
[6] 2-Y
[7] Meinert CL, 1986, CLIN TRIALS DESIGN C, P214
[8] End-point interpretation in clinical trials:: The case for discipline
Moyé, LA
[J]. CONTROLLED CLINICAL TRIALS, 1999, 20 (01): : 40 - 49
[9] Moyé LA, 2000, STAT MED, V19, P767, DOI 10.1002/(SICI)1097-0258(20000330)19:6<767::AID-SIM518>3.0.CO
[10] 2-U

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