Progress in liquid chromatography-mass spectrometry instrumentation and its impact on high-throughput screening

被引：129

作者：

Niessen, WMA

机构：

[1] Hyphen Mass Spec Consultancy, NL-2332 XT Leiden, Netherlands

[2] Fac Sci, Dept Analyt Chem & Appl Spect, NL-1081 HV Amsterdam, Netherlands

来源：

JOURNAL OF CHROMATOGRAPHY A | 2003年 / 1000卷 / 1-2期

关键词：

reviews; instrumentation; LC-MS; liquid chromatography-mass spectrometry; interfaces; ionization techniques; mass analysis; high-throughput screening;

D O I：

10.1016/S0021-9673(03)00506-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past 10 years, liquid chromatography-mass spectrometry (LC-MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC-MS-related interfacing, ionization and mass analysis are reviewed from the perspective of the application of LC-MS in high-throughput screening of combinatorial libraries and the related high-throughput quantitative bioanalysis in early drug-discovery studies, such as early adsorption, distribution, metabolism and excretion studies. (C) 2003 Elsevier Science B.V. All rights reserved.

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收藏

页码：413 / 436

页数：24

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