Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

被引：205

作者：

Celli, Jean ^{[1
]}

Tsolis, Renee M. ^{[2
]}

机构：

[1] Washington State Univ, Coll Vet Med, Paul G Allen Sch Global Anim Hlth, Pullman, WA 99164 USA

[2] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 02期

关键词：

INNATE IMMUNE-RESPONSES; THIOREDOXIN-INTERACTING PROTEIN; QUALITY-CONTROL PROTEINS; LEGIONELLA-PNEUMOPHILA; SUBTILASE CYTOTOXIN; BRUCELLA-ABORTUS; SECRETION SYSTEMS; INTRACELLULAR REPLICATION; ACTIVATES TRANSCRIPTION; TRANSMEMBRANE PROTEIN;

D O I：

10.1038/nrmicro3393

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The unfolded protein response (UPR) is a cytoprotective response that is aimed at restoring cellular homeostasis following physiological stress exerted on the endoplasmic reticulum (ER), which also invokes innate immune signalling in response to invading microorganisms. Although it has been known for some time that the UPR is modulated by various viruses, recent evidence indicates that it also has multiple roles during bacterial infections. In this Review, we describe how bacteria interact with the ER, including how bacteria induce the UPR, how subversion of the UPR promotes bacterial proliferation and how the UPR contributes to innate immune responses against invading bacteria.

引用

页码：71 / 82

页数：12

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