Tuning the enantioselective N-acetylation of racemic amines: A spectacular salt effect

被引：44

作者：

Arseniyadis, S ^{[1
]}

Subhash, PV ^{[1
]}

Valleix, A ^{[1
]}

Mathew, SP ^{[1
]}

Blackmond, DG ^{[1
]}

Wagner, A ^{[1
]}

Mioskowski, C ^{[1
]}

机构：

[1] Univ Strasbourg 1, Fac Pharm, CNRS, Lab Synthese Bioorgan Associe, F-67401 Illkirch Graffenstaden, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 17期

关键词：

D O I：

10.1021/ja051302+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have described a spectacular salt effect in the kinetic resolution of (±)-1-phenylethylamine, which leads to an increase in reactivity, high levels of selectivity, and a complete reversal of the stereoselectivity. By tuning the reaction conditions, we were able to increase the selectivity factor of (1S,2S)-1 to s = 115. Copyright © 2005 American Chemical Society.

引用

页码：6138 / 6139

页数：2

共 18 条

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