Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility

被引:126
作者
Hauser, R
Williams, P
Altshul, L
Calafat, AM
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Occupat Hlth Program, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Vincent Mem Obstet & Gynecol Serv, Androl Lab, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, In Vitro Fertilizat Unit, Boston, MA 02114 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Environm Sci & Engn Program, Boston, MA 02115 USA
[6] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA
关键词
D O I
10.1289/ehp.7305
中图分类号
X [环境科学、安全科学];
学科分类号
08 [工学]; 0830 [环境科学与工程];
摘要
Previously, we reported evidence of inverse associations between exposure to some polychlorinated biphenyls (PCBs) and some phthalate monoesters in relation to semen parameters, specifically sperm motility. Because humans are exposed to both phthalates and PCBs and because experimental studies suggest that PCBs may interact with glucuronidative enzymes that are responsible for phthalate metabolism, we explored the potential interaction between phthalates and PCBS in relation to human semen quality. We studied 303 men who were partners in subfertile couples seeking infertility diagnosis from the andrology laboratory at Massachusetts General Hospital. Semen parameters were dichotomized based on World Health Organization reference values, and plithalate and PCB levels were dichotomized at their respective medians. After adjusting for age and abstinence time, for below reference sperm motility there was a greater than additive interaction between monobenzyl plithalate and PCB-153 [relative excess risk due to interaction (RERI) = 1.40; 95% confidence interval (CI), 0.41-3.22], sum of PCBs (RERI = 1.24; 95% Cl, 0.15-2.94), and cytochrome P450 (CYP450)-inducing PCBs (RERI = 1.30; 95% CI, 0.21-3.06). For below-reference sperm motility, there was also a greater than additive interaction between monobutyl phthalate (MBP) and PCB-153 (RERI = 1.42; 95% CI, 0.09-3.76) and CYP450-inducing PCBs (RERI = 1.87; 95% CI, 0.56-4.52) and a suggestive interaction between MBP and sum of PCBs (RERI = 1.35; 95% CI, -0.11 to 3.48). In conclusion, because there are important risk assessment and public health implications of interactions between these two ubiquitous classes of compounds, further studies need to be conducted to confirm these results and identify potential mechanisms of interactions.
引用
收藏
页码:425 / 430
页数:6
相关论文
共 40 条
[1]
ADVERSE-EFFECTS OF BUTYL BENZYL PHTHALATE ON THE REPRODUCTIVE AND HEMATOPOIETIC SYSTEMS OF MALE-RATS [J].
AGARWAL, DK ;
MARONPOT, RR ;
LAMB, JC ;
KLUWE, WM .
TOXICOLOGY, 1985, 35 (03) :189-206
[2]
Confidence intervals for measures of interaction [J].
Assmann, SF ;
Hosmer, DW ;
Lemeshow, S ;
Mundt, KA .
EPIDEMIOLOGY, 1996, 7 (03) :286-290
[3]
SELECTIVE RETENTION OF HYDROXYLATED PCB METABOLITES IN BLOOD [J].
BERGMAN, A ;
KLASSONWEHLER, E ;
KUROKI, H .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 (05) :464-469
[4]
BLACKWELL JM, 1992, FERTIL STERIL, V58, P798
[5]
POLYCHLOROBIPHENYL CONGENERS, P,P'-DDE, AND SPERM FUNCTION IN HUMANS [J].
BUSH, B ;
BENNETT, AH ;
SNOW, JT .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1986, 15 (04) :333-341
[6]
STUDIES ON DIBUTYL PHTHALATE-INDUCED TESTICULAR ATROPHY IN RAT - EFFECT ON ZINC-METABOLISM [J].
CATER, BR ;
COOK, MW ;
GANGOLLI, SD ;
GRASSO, P .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1977, 41 (03) :609-618
[7]
*CDC, 2003, 2 CDC CDCP
[8]
Decreased human semen quality and organochlorine compounds in blood [J].
Dallinga, JW ;
Moonen, EJC ;
Dumoulin, JCM ;
Evers, JLH ;
Geraedts, JPM ;
Kleinjans, JCS .
HUMAN REPRODUCTION, 2002, 17 (08) :1973-1979
[9]
Phthalate exposure and human semen parameters [J].
Duty, SM ;
Silva, MJ ;
Barr, DB ;
Brock, JW ;
Ryan, L ;
Chen, ZY ;
Herrick, RF ;
Christiani, DC ;
Hauser, R .
EPIDEMIOLOGY, 2003, 14 (03) :269-277
[10]
Fängström B, 2002, ENVIRON HEALTH PERSP, V110, P895, DOI 10.1289/ehp.02110895