Rituximab can be useful as treatment for minimal residual disease in bcr-abl-positive acute lymphoblastic leukemia

被引：29

作者：

Jándula, BM

Nomdedeu, J

Marín, P

Vivancos, P

机构：

[1] Ctr Med Teknon, Inst Hematol Torre Vilana, Barcelona 08022, Spain

[2] Hosp Sant Creu & Sant Pau, Dept Hematol, Barcelona, Spain

[3] Hosp Clin Barcelona, Cryobiol Lab, Barcelona, Spain

来源：

BONE MARROW TRANSPLANTATION | 2001年 / 27卷 / 02期

关键词：

Rituximab; ALL; bcr-abl rearrangement;

D O I：

10.1038/sj.bmt.1702706

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report the results of administering CD20 monoclonal antibody (MoAb) in a 32-year-old man with bcr-abl-positive acute lymphoblastic leukemia. Morphological complete remission was achieved after two lines of chemotherapy with persistence of blast cells (2%) in flow cytometric analysis of marrow cells. Since no HLA-matched donor for allogeneic bone marrow transplantation (BMT) was found, anti-CD20 MoAb therapy was administered for in vivo marrow purging, prior to autologous peripheral blood stem cell (PBSC) harvest and transplantation. After MoAb therapy <0.1% of blast cells were observed and the molecular abnormality (bcr-abl gene rearrangement) disappeared.

引用

页码：225 / 227

页数：3

共 11 条

[1] Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads:: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction [J].

Atta, J ;

Fauth, F ;

Keyser, M ;

Petershofen, E ;

Weber, C ;

Lippok, G ;

Hoelzer, D ;

Martin, H .

BONE MARROW TRANSPLANTATION, 2000, 25 (01) :97-104

[2]

BARRETT AJ, 1992, BLOOD, V79, P3067

[3]

BAST RC, 1985, CANCER RES, V45, P499

[4]

Canals C, 1994, Prog Clin Biol Res, V389, P125

[5]

GOCKBUGET N, 1999, SCHWEIZ RUNDSCH MED, V88, P407

[6]

GUYOTAT D, 1990, BONE MARROW TRANSPL, V6, P385

[7]

HOELZER D, 1994, SEMIN HEMATOL, V31, P1

[8]

Martin H, 1998, BONE MARROW TRANSPL, V21, pS2

[9]

Muñoz L, 2000, HAEMATOLOGICA, V85, P704

[10] Detection of bcr-abl transcripts in Philadelphia chromosome-positive acute lymphoblastic leukemia after marrow transplantation [J].

Radich, J ;

Gehly, G ;

Lee, A ;

Avery, R ;

Bryant, E ;

Edmands, S ;

Gooley, T ;

Kessler, P ;

Kirk, J ;

Ladne, P ;

Thomas, ED ;

Appelbaum, FR .

BLOOD, 1997, 89 (07) :2602-2609

← 1 2 →