Reduced Human Beta Defensin 3 in Individuals with Periodontal Disease

被引：61

作者：

Brancatisano, F. L. ^{[1
]}

Maisetta, G. ^{[1
]}

Barsotti, F. ^{[1
,2
]}

Esin, S. ^{[1
]}

Miceli, M. ^{[2
]}

Gabriele, M. ^{[2
]}

Giuca, M. R. ^{[2
]}

Campa, M. ^{[1
]}

Batoni, G. ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Patol Sperimentale Biotecnol Med Inf, I-56127 Pisa, Italy

[2] Univ Pisa, Sez Chirurg Orale, Dipartimento Chirurg, I-56127 Pisa, Italy

来源：

JOURNAL OF DENTAL RESEARCH | 2011年 / 90卷 / 02期

关键词：

antimicrobial peptides; human beta defensin-3; gingival crevicular fluid; periodontal pathogens; periodontitis; HUMAN BETA-DEFENSIN-3; ANTIMICROBIAL PEPTIDES; EXPRESSION; INDUCTION; IDENTIFICATION; PATHOGENS; HEALTH;

D O I：

10.1177/0022034510385686

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

The human beta defensin 3 (hBD3) is widely expressed in the oral cavity and exerts strong antibacterial and immunomodulatory activities. Hence, we hypothesized that hBD3 could play a protective role in the maintenance of periodontal homeostasis, and that it could be found in gingival crevicular fluid (GCF) of healthy individuals and those with periodontitis at levels correlating with the degree of periodontal health. By using an ELISA assay to quantify hBD3 in GCF, we demonstrated that the peptide is present at levels easily detectable in the majority of healthy individuals, but it is drastically reduced in GCF from those with periodontitis. Furthermore, hBD3 levels inversely correlate with the severity of the disease and the degree of colonization by combinations of bacterial species with elevated periodontopathogenic potential. Both genetic factors and host/bacterial proteases released in diseased sites may be responsible for the observed low/null hBD3 levels in GCF from individuals with periodontitis.

引用

页码：241 / 245

页数：5

共 27 条

[1]

Expression of β-defensins in gingival health and in periodontal disease [J].