Repetitive, negligible force reaching in rats induces pathological overloading of upper extremity bones

被引：40

作者：

Barr, AE ^{[1
]}

Safadi, FF

Gorzelany, I

Amin, M

Popoff, SN

Barbe, MF

机构：

[1] Temple Univ, Coll Hlth Profess, Dept Phys Therapy, Philadelphia, PA 19122 USA

[2] Temple Univ, Sch Med, Dept Anat & Cell Biol, Philadelphia, PA 19122 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 11期

关键词：

osteoclast; macrophage; inflammation; repetitive motion; work-related musculoskeletal disorder;

D O I：

10.1359/jbmr.2003.18.11.2023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Work-related repetitive motion disorders are costly. Immunohistochemical changes in bones resulting from repetitive reaching and grasping in 17 rats were examined. After 3-6 weeks, numbers of ED1(+) macrophages and osteoclasts increased at periosteal surfaces of sites of muscle and interosseous membrane attachment and metaphyses of reach and nonreach forelimbs. These findings indicate pathological overloading leading to inflammation and subsequent bone resorption.

引用

页码：2023 / 2032

页数：10

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