CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

被引：808

作者：

Altarejos, Judith Y. ^{[1
,2
]}

Montminy, Marc ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Peptide Biol Labs, La Jolla, CA 92037 USA

[2] Sanford Burnham Med Res Inst Lake Nona, Orlando, FL 32827 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ELEMENT-BINDING PROTEIN; GENOME-WIDE ANALYSIS; PROMOTER-REGULATORY REGION; MEDIATED GENE-EXPRESSION; RNA-POLYMERASE-II; TRANSCRIPTION-FACTOR; CYCLIC-AMP; HEPATIC GLUCONEOGENESIS; MODULATES GLUCONEOGENESIS; GLUCOSE-HOMEOSTASIS;

D O I：

10.1038/nrm3072

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response to a wide variety of signals, yet target gene transcription is only increased in a subset of cases. Recent studies indicate that CREB functions in concert with a family of latent cytoplasmic co-activators called cAMP-regulated transcriptional co-activators (CRTCs), which are activated through dephosphorylation. A dual requirement for CREB phosphorylation and CRTC dephosphorylation is likely to explain how these activator-co-activator cognates discriminate between different stimuli. Following their activation, CREB and CRTCs mediate the effects of fasting and feeding signals on the expression of metabolic programmes in insulin-sensitive tissues.

引用

页码：141 / 151

页数：11

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