Compound efflux in Helicobacter pylori

被引：51

作者：

Kutschke, A ^{[1
]}

de Jonge, BLM ^{[1
]}

机构：

[1] AstraZeneca R&D Boston, Infect Discovery, Canc & Infect Res Area, Waltham, MA 02451 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 07期

关键词：

D O I：

10.1128/AAC.49.7.3009-3010.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Susceptibility testing with a variety of structurally unrelated compounds showed that hefC in Helicobacter pylori is involved in multidrug efflux. This efflux was shown to depend on the proton motive force, as demonstrated by ethidium bromide accumulation experiments. Thus, H. pylori contains an active multidrug efflux mechanism.

引用

页码：3009 / 3010

页数：2

共 12 条

[1] Helicobacter pylori uptake and efflux:: Basis for intrinsic susceptibility to antibiotics in vitro [J].

Bina, JE ;

Alm, RA ;

Uria-Nickelsen, M ;

Thomas, SR ;

Trust, TJ ;

Hancock, REW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) :248-254

[2] The structure and function of drug pumps [J].

Borges-Walmsley, MI ;

Walmsley, AR .

TRENDS IN MICROBIOLOGY, 2001, 9 (02) :71-79

[3] Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar typhimurium [J].

Giraud, E ;

Cloeckaert, A ;

Kerboeuf, D ;

Chaslus-Dancla, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (05) :1223-1228

[4]

HAMAN KE, 1995, MICROBIOLOGY, V141, P611

[5] ROLE OF MEXA-MEXB-OPRM IN ANTIBIOTIC EFFLUX IN PSEUDOMONAS-AERUGINOSA [J].

LI, XZ ;

NIKAIDO, H ;

POOLE, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (09) :1948-1953

[6] CmeABC functions as a multidrug efflux system in Campylobacter jejuni [J].

Lin, J ;

Michel, LO ;

Zhang, QJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (07) :2124-2131

[7] Multidrug efflux pumps of gram-negative bacteria [J].

Nikaido, H .

JOURNAL OF BACTERIOLOGY, 1996, 178 (20) :5853-5859

[8] Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those β-lactam antibiotics containing lipophilic side chains [J].

Nikaido, H ;

Basina, M ;

Nguyen, V ;

Rosenberg, EY .

JOURNAL OF BACTERIOLOGY, 1998, 180 (17) :4686-4692

[9] Proton-dependent multidrug efflux systems [J].

Paulsen, IT ;

Brown, MH ;

Skurray, RA .

MICROBIOLOGICAL REVIEWS, 1996, 60 (04) :575-+

[10] Molecular properties of bacterial multidrug transporters [J].

Putman, M ;

van Veen, HW ;

Konings, WN .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (04) :672-+

← 1 2 →