Nonlinear Decline of Mini-Mental State Examination in Parkinson's Disease

被引：39

作者：

Aarsland, Dag ^{[1
,2
]}

Muniz, Graciela ^{[3
]}

Matthews, Fiona ^{[3
]}

机构：

[1] Stavanger Univ Hosp, Div Psychiat, Ctr Age Related Med, N-4068 Stavanger, Norway

[2] Univ Oslo, Akershus Univ Hosp, Sect Clincal MEdcin, Oslo, Norway

[3] MRC, Biostat Unit, Cambridge CB2 2BW, England

来源：

MOVEMENT DISORDERS | 2011年 / 26卷 / 02期

基金：

英国医学研究理事会;

关键词：

Parkinson's disease; cognitive impairment; course; nonlinear; COGNITIVE DECLINE; DEMENTIA;

D O I：

10.1002/mds.23416

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used the mini-mental state examination (MMSE) to assess the longitudinal cognitive course. We observed that the rate of global cognitive decline was nonlinear. Following a relatively stable period, an inflection point was identified, after which the rate of decline gained momentum with an annual decline of 2.8 points on the MMSE. The course was similar in men and women. This inflection point was estimated to occur 13.3 years (95% credible interval 11.8, 13.6) after the diagnosis of PD; however, there were wide interindividual variations in the time from onset of PD to the inflection point. (C) 2010 Movement Disorder Society

引用

页码：334 / 337

页数：4

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