The relationship between albuminuria and hormone therapy in postmenopausal women

被引:45
作者
Agarwal, M
Selvan, V
Freedman, BI
Liu, YM
Wagenknecht, LE
机构
[1] Wake Forest Univ Hlth Sci, Dept Internal Med Nephrol, Winston Salem, NC 27157 USA
[2] Wake Forest Univ Hlth Sci, Dept Hypertens, Winston Salem, NC 27157 USA
[3] Wake Forest Univ Hlth Sci, Dept Publ Hlth Sci, Winston Salem, NC 27157 USA
关键词
urine albumin-creatinine ratio (ACR); postmenopausal; hormone therapy; women;
D O I
10.1053/j.ajkd.2005.02.025
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background Elevated urinary albumin excretion and hormone therapy (HT) are associated with increased risk for cardiovascular events. We assessed the relationship between albuminuria and the use of hormonal preparations in postmenopausal women. Methods: Data from the Insulin Resistance Atherosclerosis Study were obtained at baseline and 5-year follow-up for analysis. The generalized estimating equation procedure accounting for repeated measures was used for this analysis. HT was the main predictor variable, and log, urine albumin-creatinine ratio (ACR) was the main outcome variable. Results: Four hundred ninety-one menopausal women were included in the analysis, 36% (n = 179) of whom received HT (either oral estrogen, progesterone, or combination therapy). At baseline, abnormal alburninuria (ACR 2:25 mg/g) was present in 11% of women on HT and 17% not on HT (P = 0.02). After adjusting for demographics, the presence of diabetes and hypertension, and kidney function, HT was associated with a 19% reduction in ACR (P = 0.008) and an odds ratio of 0.67 (95% confidence interval, 0.43 to 1.01; P = 0.06) for the presence of abnormal albuminuria. Other predictors of abnormal albuminuria included diabetes, blood pressure, and triglyceride level. Conclusion: Results of this study suggest that HT is associated with a reduction in urinary albumin excretion in postmenopausal women. (c) 2005 by the National Kidney Foundation, Inc.
引用
收藏
页码:1019 / 1025
页数:7
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