Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

被引：236

作者：

Ma, ZG

Morris, SW

Valentine, V

Li, M

Herbrick, JA

Cui, XL

Bouman, D

Li, Y

Mehta, PK

Nizetic, D

Kaneko, Y

Chan, GCF

Chan, LC

Squire, J

Scherer, SW

Hitzler, JK ^{[1
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Hosp Sick Children, Dept Canc & Blood, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Hosp Sick Children, Dept Genet, Toronto, ON M5G 1X8, Canada

[4] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[5] St Jude Childrens Res Hosp, Dept Tumor Cell Biol, Memphis, TN 38105 USA

[6] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

[7] St Jude Childrens Res Hosp, Hartwell Ctr Bioinformat & Biotechnol, Memphis, TN 38105 USA

[8] Univ Tennessee, Coll Med, Dept Pediat, Memphis, TN 38163 USA

[9] Univ London, Sch Pharm, Ctr Appl Mol Biol, London WC1N 1AX, England

[10] Saitama Canc Ctr Hosp, Dept Canc Chemotherapy, Ina, Saitama 3630806, Japan

[11] Univ Hong Kong, Queen Mary Hosp, Dept Paediat, Div Haematol, Hong Kong, Hong Kong, Peoples R China

[12] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Div Haematol, Hong Kong, Hong Kong, Peoples R China

[13] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A8, Canada

[14] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

[15] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

来源：

NATURE GENETICS | 2001年 / 28卷 / 03期

关键词：

D O I：

10.1038/90054

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes. RNA-binding motif protein-15 (RBM15). an RNA recognition motif-encoding gene with homology to Drosophila spen. and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B. Acinus and PIAS) DNA-binding domain.

引用

页码：220 / 221

页数：2

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