The osteoclast-what's new?

被引：11

作者：

Athanasou, Nicolas A. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Orthopaed Ctr, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford OX3 7LD, England

来源：

SKELETAL RADIOLOGY | 2011年 / 40卷 / 09期

关键词：

Osteoclasts; Bone resorption; Skeletal modelling; OSTEOPROTEGERIN LIGAND; PAGET-DISEASE; BONE; DIFFERENTIATION; ACTIVATION; CELLS;

D O I：

10.1007/s00256-011-1180-9

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Bone resorption is required for skeletal modelling during bone growth and for mineral homeostasis and bone remodelling throughout life. Osteoclasts are multinucleated cells that are uniquely specialised to carry out this physiological bone resorption. As osteolysis is a feature of most diseases of bone and joint, osteoclasts also play a role in pathological bone resorption, the extent of which is a function of the cellular and molecular mechanisms that govern their formation and function.

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收藏

页码：1137 / 1140

页数：4

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