The genetics of cancer - a 3D model

被引：109

作者：

Cole, KA

Krizman, DB

Emmert-Buck, MR

机构：

[1] NCI, Pathol Lab, Pathogenet Unit, Bethesda, MD 20892 USA

[2] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA

[3] NCI, Canc Genome Anat Project, Off Director, Bethesda, MD 20892 USA

来源：

NATURE GENETICS | 1999年 / 21卷 / Suppl 1期

关键词：

D O I：

10.1038/4466

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene expression microarrays hold great promise for studies of human disease states. There are significant technical issues specific to utilizing clinical tissue samples which have yet to be rigorously addressed and completely overcome. Precise, quantitative measurement of gene expression profiles:from specific cell populations is at hand, offering the scientific community the first comprehensive View of the in vivo molecular anatomy of normal cells and their diseased counterparts. Here. we propose a model-for integrating-in three dimensions-expression data obtained using the microarray.

引用

页码：38 / 41

页数：4

共 50 条

[1]

Abbott A, 1996, NATURE, V379, P392

[2] Gene expression informatics - it's all in your mine [J].