Human adipose-derived mesenchymal progenitor cells plus microfracture and hyaluronic acid for cartilage repair: a Phase IIa trial

被引：38

作者：

Qiao, Zhiguang ^{[1
,2
]}

Tang, Jiaxin ^{[1
,3
]}

Yue, Bing ^{[4
]}

Wang, Jinwu ^{[1
]}

Zhang, Jun ^{[1
]}

Xuan, Liang ^{[1
]}

Dai, Chengxiang ^{[5
]}

Li, Suke ^{[5
]}

Li, Meng ^{[5
]}

Xu, Cuili ^{[5
]}

Dai, Kerong ^{[4
]}

Wang, You ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Orthopaed Implants, Shanghai Peoples Hosp 9, Dept Orthopaed Surg,Sch Med, Shanghai 200011, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Med 3D Printing Innovat Res Ctr, Shanghai 200125, Peoples R China

[3] Tongji Univ, Sch Med, Shanghai Peoples Hosp 4, Dept Bone & Joint Surg, Shanghai 200081, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Bone & Joint Surg, Shanghai 200020, Peoples R China

[5] Cellular Biomed Grp, Shanghai 201210, Peoples R China

来源：

REGENERATIVE MEDICINE | 2020年 / 15卷 / 01期

关键词：

Artz; cartilage defect; cartilage regeneration; human adipose-derived mesenchymal progenitor cells; microfracture; Re-Join((R)); STROMAL-VASCULAR FRACTION; STEM-CELLS; CHONDRAL DEFECTS; INTRAARTICULAR INJECTION; ARTHROSCOPIC SURGERY; ARTICULAR-CARTILAGE; KNEE; OSTEOARTHRITIS; IMPLANTATION; THERAPY;

D O I：

10.2217/rme-2019-0068

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Aim: This study aimed to preliminarily evaluate the safety and efficacy of human adipose-derived mesenchymal progenitor cells (haMPCs) in combination with microfracture and hyaluronic acid (HA) for treating cartilage defects. Materials & methods: A total of 30 patients with medial femoro-tibial condylar cartilage defects were randomized into three groups: arthroscopic microfracture group and normal saline injection, arthroscopic microfracture and intra-articular injection of HA, or arthroscopic microfracture in combination with intra-articular injection of HA and haMPCs. Results & conclusions: The data demonstrated that intra-articular injection of haMPCs plus microfracture and HA is a safe procedure to improve joint function in patients with knee cartilage defects. These findings provide an impetus for future research on this treatment. ClinicalTrials.gov Identifier: NCT02855073 Graphical abstract

引用

页码：1193 / 1214

页数：22

共 61 条

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