Genomically humanized mice: technologies and promises

被引：73

作者：

Devoy, Anny ^{[1
]}

Bunton-Stasyshyn, Rosie K. A. ^{[1
]}

Tybulewicz, Victor L. J. ^{[2
]}

Smith, Andrew J. H. ^{[3
,4
]}

Fisher, Elizabeth M. C. ^{[1
]}

机构：

[1] UCL Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3BG, England

[2] MRC Natl Inst Med Res, London NW7 1AA, England

[3] Univ Edinburgh, Inst Stem Cell Res, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland

[4] Univ Oxford, John Radcliffe Hosp, MRC Mol Haematol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

MEDIATED CASSETTE EXCHANGE; KNOCK-IN MICE; MOUSE GENOME; CARRYING HUMAN-CHROMOSOME-21; HUMAN-ANTIBODIES; MAMMALIAN-CELLS; TRANSGENIC MICE; EXPRESSION; MODEL; RECOMBINASE;

D O I：

10.1038/nrg3116

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success.

引用

页码：14 / 20

页数：7

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