Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report

被引：7

作者：

Spaas, J. H. ^{[1
]}

Oosterlinck, M. ^{[2
]}

Broeckx, S. ^{[3
]}

Dumoulin, M. ^{[2
]}

Saunders, J. ^{[4
]}

Van Soom, A. ^{[3
]}

Pille, F. ^{[2
]}

Van de Walle, G. R. ^{[1
]}

机构：

[1] Univ Ghent, Fac Vet Med, Dept Comparat Physiol & Biometr, B-9820 Merelbeke, Belgium

[2] Univ Ghent, Fac Vet Med, Dept Surg & Anesthesiol Domest Anim, B-9820 Merelbeke, Belgium

[3] Univ Ghent, Fac Vet Med, Dept Reprod Obstet & Herd Hlth, B-9820 Merelbeke, Belgium

[4] Univ Ghent, Fac Vet Med, Dept Vet Med Imaging & Small Anim Orthoped, B-9820 Merelbeke, Belgium

来源：

VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT | 2012年 / 81卷 / 01期

关键词：

BONE-MARROW; STROMAL CELLS; THERAPY; TENDON; HORSE; IMPLANTATION;

D O I：

10.21825/vdt.v81i1.18372

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

A 5-year-old German Warmblood stallion with chronic lameness, attributable to degenerative joint disease (DJD) of the pastern joint unresponsive to medical treatments, was treated with autologous mesenchymal stem cells (MSC). These MSC were isolated from the peripheral blood (PB) of the patient and injected into the pastern joint, at a concentration of 2.5x10(6) cells, twice with an 8-week interval. The positive response to this stem cell treatment was documented by visual gait evaluation as well as objective pressure plate analyses. This paper is the first to describe the use of autologous PB-derived MSC to treat a horse suffering from chronic DJD. The favorable outcome of this single case may stimulate further research on the use of equine peripheral blood as a source of autologous MSC in equine regenerative medicine.

引用

页码：11 / 15

页数：5

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