Therapeutic Potential of High Mobility Group Box-1 in Ischemic Injury and Tissue Regeneration

被引:61
作者
Biscetti, Federico [1 ]
Ghirlanda, Giovanni [1 ]
Flex, Andrea [1 ]
机构
[1] Univ Cattolica Sacro Cuore, Sch Med, A Gemelli Univ Hosp, Lab Vasc Biol & Genet,Dept Med, I-00168 Rome, Italy
关键词
High-mobility group box-1; HMGB1; angiogenesis; tissue regeneration; ischemic diseases; degenerative diseases; vascular endothelial growth factor; VEGF; ENDOTHELIAL GROWTH-FACTOR; HIGH-MOBILITY-GROUP-BOX-1; PROTEIN; LIVER ISCHEMIA; HMGB1; CELLS; ANGIOGENESIS; DISEASE; DIFFERENTIATION; PROLIFERATION; INFLAMMATION;
D O I
10.2174/157016111797484125
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
High-mobility group box-1 (HMGB1) is a nuclear protein that acts as a cytokine when released into the extracellular milieu by necrotic and inflammatory cells, and is involved in inflammatory responses and tissue repair. This protein is released passively during cellular necrosis by almost all cells that have a nucleus, but is also actively secreted by immune cells such as macrophages and monocytes. This cytokine plays a key role in mediating the local and systemic responses to several stimuli and might have therapeutic relevance. Indeed, vessel-associated stem cells, injected into the general circulation of dystrophic mice, migrate to sites of tissue damage in response to the HMGB1 signal, by a nuclear factor-kappa B-dependent mechanism. Moreover, endogenous HMGB1 enhances angiogenesis and restores cardiac function in a murine model of myocardial infarction, and the exogenous administration of HMGB1 after myocardial infarction leads to the recovery of left ventricular function through the regeneration of cardiomyocytes. Finally, recent findings show that endogenous HMGB1 is crucial for ischemia-induced angiogenesis in diabetic mice and that HMGB1 protein administration enhances collateral blood flow in the ischemic hind limbs of diabetic mice through a VEGF-dependent manner. The mechanisms of action of this protein are complex and are not well known or defined. The objective of this review is to evaluate the data regarding the tissue regeneration effects of HMGB1, with the aim of providing practical considerations about this topic for the management of subjects affected by ischemic and degenerative diseases.
引用
收藏
页码:677 / 681
页数:5
相关论文
共 42 条
[1]
Rebuilding the Damaged Heart The Potential of Cytokines and Growth Factors in the Treatment of Ischemic Heart Disease [J].
Beohar, Nirat ;
Rapp, Jonathan ;
Pandya, Sanjay ;
Losordo, Douglas W. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (16) :1287-1297
[2]
Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury [J].
Bersell, Kevin ;
Arab, Shima ;
Haring, Bernhard ;
Kuehn, Bernhard .
CELL, 2009, 138 (02) :257-270
[3]
High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity [J].
Bianchi, Marco E. ;
Manfredi, Angelo A. .
IMMUNOLOGICAL REVIEWS, 2007, 220 :35-46
[4]
DAMPs, PAMPs and alarmins: all we need to know about danger [J].
Bianchi, Marco E. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (01) :1-5
[5]
High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism [J].
Biscetti, Federico ;
Straface, Giuseppe ;
De Cristofaro, Raimondo ;
Lancellotti, Stefano ;
Rizzo, Paola ;
Arena, Vincenzo ;
Stigliano, Egidio ;
Pecorini, Giovanni ;
Egashira, Kensuke ;
De Angelis, Giulia ;
Ghirlanda, Giovanni ;
Flex, Andrea .
DIABETES, 2010, 59 (06) :1496-1505
[6]
Revised nomenclature for high mobility group (HMG) chromosomal proteins [J].
Bustin, M .
TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (03) :152-153
[7]
Angiogenesis in health and disease [J].
Carmeliet, P .
NATURE MEDICINE, 2003, 9 (06) :653-660
[8]
Multiple effects of high mobility group box protein 1 in skeletal muscle regeneration [J].
De Mori, Roberta ;
Straino, Stefania ;
Di Carlo, Anna ;
Mangoni, Antonella ;
Pompilio, Giulio ;
Palumbo, Roberta ;
Bianchi, Marco E. ;
Capogrossi, Maurizio C. ;
Germani, Antonia .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (11) :2377-2383
[9]
The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells [J].
Degryse, B ;
Bonaldi, T ;
Scaffidi, P ;
Müller, S ;
Resnati, M ;
Sanvito, F ;
Arrigoni, G ;
Bianchi, ME .
JOURNAL OF CELL BIOLOGY, 2001, 152 (06) :1197-1206
[10]
Analysis and verification of the HMGB1 signaling pathway [J].
Gong, Haijun ;
Zuliani, Paolo ;
Komuravelli, Anvesh ;
Faeder, James R. ;
Clarke, Edmund M. .
BMC BIOINFORMATICS, 2010, 11