mTOR: A Cellular Regulator Interface in Health and Disease

被引:152
作者
Boutouja, Fahd [1 ]
Stiehm, Christian M. [1 ]
Platta, Harald W. [1 ]
机构
[1] Ruhr Univ Bochum, Biochem Intrazellularer Transportprozesse, D-44801 Bochum, Germany
关键词
mTOR; autophagy; kinase; phosphorylation; aging; cancer; TUMOR-SUPPRESSOR COMPLEX; LIFE-SPAN EXTENSION; AMINO-ACID LEVELS; MAMMALIAN TARGET; TUBEROUS-SCLEROSIS; RAPAMYCIN TREATMENT; RAG GTPASES; CARDIAC-HYPERTROPHY; STRUCTURAL BASIS; BINDING PARTNER;
D O I
10.3390/cells8010018
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and orchestrating their physiologic effects on cellular level. mTOR is the core component of differently composed signaling complexes that differ in protein composition and molecular targets. Newly identified classes of mTOR inhibitors are being developed to block autoimmune diseases and transplant rejections but also to treat obesity, diabetes, and different types of cancer. Therefore, the selective and context-dependent inhibition of mTOR activity itself might come into the focus as molecular target to prevent severe diseases and possibly to extend life span. This review provides a general introduction to the molecular composition and physiologic function of mTOR complexes as part of the Special Issue "2018 Select Papers by Cells' Editorial Board Members".
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页数:23
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