Non-isomerized C-telopeptide fragments are highly sensitive markers for monitoring disease activity and treatment efficacy in Paget's disease of bone

被引：31

作者：

Alexandersen, P

Peris, P

Guañabens, N

Byrjalsen, I

Alvarez, L

Solberg, H

Cloos, PAC

机构：

[1] Ctr Clin & Basic Res, DK-2750 Ballerup, Denmark

[2] Univ Barcelona, Serv Rheumatol, Hosp Clin, Barcelona, Spain

[3] Inst Invest Biomed August Pi I Sunyer, Metab Bone Dis Unit, Barcelona, Spain

[4] Nord Biosci, Herlev, Denmark

[5] Univ Barcelona, Serv Clin Biochem, Hosp Clin, Barcelona, Spain

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 04期

关键词：

Paget's disease; bone turnover markers; collagen; aging; bisphosphonates;

D O I：

10.1359/JBMR.041212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A new resorption assay measuring non-isomerized collagen type I C-telopeptide fragments (alpha-alpha CTX) was evaluated in a cohort comprising 32 Pagetic patients and 48 healthy controls. alpha-alpha CTX was found to be a sensitive marker for assessing disease activity and monitoring treatment efficacy in Paget's disease of bone compared with isomerized CTX (beta-beta CTX) and a number of other established bone turnover markers.

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收藏

页码：588 / 595

页数：8

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