Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel

被引：60

作者：

Lee, Michael P. H. ^{[1
]}

Parkinson, Gary N. ^{[1
]}

Hazel, Pascale ^{[1
]}

Neidle, Stephen ^{[1
]}

机构：

[1] Univ London, Sch Pharm, CRUK Biomol Struct Grp, London WC1N 1AX, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 33期

关键词：

D O I：

10.1021/ja0740869

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crystal structure of a DNA quadruplex, d(TGGGGT), crystallized in the presence of calcium and sodium ions, shows the presence of both ions in the central channel of the structure. This was verified by anomalous dispersion maps, which unequivocally showed the presence of calcium ions.

引用

页码：10106 / +

页数：3

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