Pre-discharge B-type natriuretic peptide predicts early recurrence of decompensated heart failure in patients admitted to a general medical unit

Background: B-type natriuretic peptide (BNP) represents a promising predictor of early (30 days) re-admission in patients with heart failure (HF) admitted to cardiology units. Whether BNP retains its predictive value in unselected patients admitted to general medical wards is unknown. Methods: We determined BNP levels on admission and pre-discharge in 100 consecutive patients (71 mate, mean age 78 10 years) admitted to a general medical unit due to decompensated HE Follow-up after discharge was 30 days. Results: Of the 100 patients, 86 had >= 1 comorbid conditions. Median BNP was 739 pg/ml on admission (25th-75th percentile 355-1333 pg/ml, respectively), and 414 pg/ml pre-discharge (25th-75th percentile 220-696 pg/ml). Seventeen patients were re-admitted or died within 30 days. Patients with pre-discharge BNP values > 75th percentile (696 pg/ml) had greater risk of re-hospitalisation, as compared to values : 696 pg/ml (56% vs. 4%, respectively; p < 0.001). Negative predictive value for this cut-off was 96%. BNP values > 75th percentile were associated with a 15.0 independent relative hazard (RH) of early re-admission or death (95% CI 4.2-53.8; p < 0.0001). The other independent predictor was a NYHA class >= III at discharge (RH 2.9; 95% CI 1.1-9.3; p < 0.05). Conclusion: In a general medical unit, pre-discharge BNP levels were a strong independent predictor of early re-admission or death due to HF, irrespective of substantial comorbidity and advanced age. (c) 2005 European Society of Cardiology. Published by Elsevier B.V All rights reserved.