Allosteric mechanisms of signal transduction

被引：555

作者：

Changeux, JP ^{[1
]}

Edelstein, SJ

机构：

[1] Inst Pasteur, F-75724 Paris, France

[2] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland

来源：

SCIENCE | 2005年 / 308卷 / 5727期

关键词：

D O I：

10.1126/science.1108595

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.

引用

收藏

页码：1424 / 1428

页数：5

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