Drug-induced hypersensitivity syndrome due to carbamazepine associated with reactivation of human herpesvirus 7

被引：16

作者：

Hara, H ^{[1
]}

Kobayashi, M ^{[1
]}

Yokoyama, A ^{[1
]}

Tochigi, M ^{[1
]}

Matsunaga, A ^{[1
]}

Shimizu, H ^{[1
]}

Goshima, J ^{[1
]}

Suzuki, H ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Dermatol, Itabashi Ku, Tokyo 1730032, Japan

来源：

DERMATOLOGY | 2005年 / 211卷 / 02期

关键词：

carbamazepine; human herpesvirus 7 (HHV-7); hypersensitivity syndrome;

D O I：

10.1159/000086449

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a 63-year-old Japanese man with epilepsy who developed skin eruptions, liver dysfunction, high fever, leukocytosis and atypical lymphocytosis 4 weeks after he had started taking carbamazepine. Titers of human herpesvirus 7 (HHV-7)-specific IgG antibodies were significantly increased and HHV-7 DNA was detected in his serum by polymerase chain reaction. These findings suggested that reactivation of HHV-7 could contribute to the development of drug-induced hypersensitivity syndrome. Copyright (c) 2005 S. Karger AG, Basel.

引用

页码：159 / 161

页数：3

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