Cell-permeable small molecule probes for site-specific labeling of proteins

被引：46

作者：

Yeo, DSY

Srinivasan, R

Uttamchandani, M

Chen, GYJ

Zhu, Q

Yao, SQ

机构：

[1] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 23期

关键词：

D O I：

10.1039/b309196a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have successfully synthesized a number of small molecule probes designed for site- specific labeling of N-terminal cysteine- containing proteins expressed in live cells. Their utility for site- specific, covalent modifications of proteins was successfully demonstrated with purified proteins in vitro, and with live bacterial cells in vivo.

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页码：2870 / 2871

页数：2

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