Drosophila immunity:: two paths to NF-κB

被引：140

作者：

Khush, RS ^{[1
]}

Leulier, F ^{[1
]}

Lemaitre, B ^{[1
]}

机构：

[1] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 05期

关键词：

D O I：

10.1016/S1471-4906(01)01887-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies of Drosophila immune responses have defined the immune deficiency (IMD) signaling pathway that mediates defense against Gramnegative bacterial infection. Like the Toll pathway, the IMD pathway regulates antimicrobial peptide gene expression via a Rel/nuclear factor (NF)-kappaB-like transcript ion fact or. However, the two pathways do not appear to share any intermediate components. Maintaining distinct immune response pathways might be one mechanism by which flies mount adapted immune responses.

引用

收藏

页码：260 / 264

页数：5

相关论文

共 39 条

[1] Toll-like receptors in the induction of the innate immune response [J].

Aderem, A ;

Ulevitch, RJ .

NATURE, 2000, 406 (6797) :782-787

[2] The apoptotic signaling pathway activated by Toll-like receptor-2 [J].

Aliprantis, AO ;

Yang, RB ;

Weiss, DS ;

Godowski, P ;

Zychlinsky, A .

EMBO JOURNAL, 2000, 19 (13) :3325-3336

[3] Toll signaling pathways in the innate immune response [J].

Anderson, KV .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) :13-19

[4] The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response [J].

Basset, A ;

Khush, RS ;

Braun, A ;

Gardan, L ;

Boccard, F ;

Hoffmann, JA ;

Lemaitre, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3376-3381

[5] A conserved signaling pathway: The Drosophila Toll-Dorsal pathway [J].

Belvin, MP ;

Anderson, KV .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :393-416

[6] Tlr4: central component of the sole mammalian LPS sensor [J].

Beutler, B .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) :20-26

[7] DREDD, a novel effector of the apoptosis activators REAPER, GRIM, and HID in Drosophila [J].

Chen, P ;

Rodriguez, A ;

Erskine, R ;

Thach, T ;

Abrams, JM .

DEVELOPMENTAL BIOLOGY, 1998, 201 (02) :202-216

[8] Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila [J].

Dushay, MS ;

Asling, B ;

Hultmark, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10343-10347

[9] Interactions between the cellular and humoral immune responses in Drosophila [J].

Elrod-Erickson, M ;

Mishra, S ;

Schneider, D .

CURRENT BIOLOGY, 2000, 10 (13) :781-784

[10] Induction and regulation of antimicrobial peptides in Drosophila [J].

Engström, Y .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 1999, 23 (4-5) :345-358

← 1 2 3 4 →