Mechanisms that regulate mechanosensory hair cell differentiation

被引：63

作者：

Müller, U ^{[1
]}

Littlewood-Evans, A ^{[1
]}

机构：

[1] Friedrich Miescher Inst, CH-4058 Basel, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(01)02046-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hair cells of the vertebrate inner ear are mechanosensors that detect sound, gravity and acceleration. They have a specialized cytoskeleton optimized for the transmission of mechanical force. Hair cell defects area major cause of deafness. The cloning of disease genes and studies of model organisms have provided insights into the mechanisms that regulate the differentiation of hair cells and their cytoskeleton. The studies have also provided new insights into the function of receptors such as integrins and protocadherins, and cytoplasmic proteins such as Rho-type GTPases and unconventional myosins, in organizing the actin cytoskeleton.

引用

页码：334 / 342

页数：9

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