Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells

被引：656

作者：

Mercer, Jason ^{[1
,2
]}

Helenius, Ari ^{[1
,2
]}

机构：

[1] ETH, Inst Biochem, CH-8093 Zurich, Switzerland

[2] ETH Honggerberg, CH-8093 Zurich, Switzerland

来源：

SCIENCE | 2008年 / 320卷 / 5875期

关键词：

D O I：

10.1126/science.1155164

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Viruses employ many different strategies to enter host cells. Vaccinia virus, a prototype poxvirus, enters cells in a pH- dependent fashion. Live cell imaging showed that fluorescent virus particles associated with and moved along filopodia to the cell body, where they were internalized after inducing the extrusion of large transient membrane blebs. p21- activated kinase 1 ( PAK1) was activated by the virus, and the endocytic process had the general characteristics of macropinocytosis. The induction of blebs, the endocytic event, and infection were all critically dependent on the presence of exposed phosphatidylserine in the viral membrane, which suggests that vaccinia virus uses apoptotic mimicry to enter cells.

引用

页码：531 / 535

页数：5

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