Palladium-catalyzed coupling reactions of bromothiophenes at the C-H bond adjacent to the sulfur atom with a new activator system, AgNO3/KF

被引：152

作者：

Kobayashi, K ^{[1
]}

Sugie, A ^{[1
]}

Takahashi, M ^{[1
]}

Masui, K ^{[1
]}

Mori, A ^{[1
]}

机构：

[1] Tokyo Inst Technol, Chem Resources Lab, Yokohama, Kanagawa 2268503, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol052063y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromothiophene derivatives react with aryl iodides catalyzed by a palladium complex in the presence of a silver(l) nitrate/potassium fluoride system to induce coupling at the C-H bond, while the carbon-bromine bond is intact. The produced coupling product bearing the C-Br bond allows further palladium-catalyzed C-C bond-forming reactions in reasonable yields.

引用

页码：5083 / 5085

页数：3

共 29 条

[1]

Ahmed MSM, 2005, B CHEM SOC JPN, V78, P160

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