Atorvastatin improves endothelial function in renal-transplant recipients

被引:49
作者
Åsberg, A [1 ]
Hartmann, A [1 ]
Fjeldså, E [1 ]
Holdaas, H [1 ]
机构
[1] Natl Hosp Norway, Dept Med, Lab Renal Physiol, Nephrol Sect, N-0027 Oslo, Norway
关键词
atorvastatin; CsA; endothelial function; kidney; nitric oxide; transplantation;
D O I
10.1093/ndt/16.9.1920
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Background. Hyperlipidaemia and endothelial dysfunction are common features in cyclosporin A (CsA)-treated renal transplant recipients. Endothelial. dysfunction may contribute to them risk of premature atherosclerosis and cardiovascular death in theses patients. A beneficial effect of statin therapy beyond cholesterol lowering may be an improvement of endothelial function. The present study was designed to assess the effect of atorvastatin on serum lipids and endothelial function in CsA treated renal transplant recipients. Methods. This pilot study was an open trial of 4 weeks atorvastatin (10 mg per day) treatment in renal transplant recipients (n=22). AR patients received a CsA- and prednisolone-based immunosuppressive regimen. Endothelial function was. assessed in the forearm skin microvasculature by acetylcholine stimulation and laser Doppler flowmetry, before and after atorvastatin treatment. Serum lipids, plasma endothelin-1 (ET-1), nitric oxide (NO), and von Willebrand factor (vWF) were also measured. Results. Both total and LDL cholesterol were significantly reduced by 26.8 +/-8.4 and 41.5 +/- 11.0% respectively, after 4 weeks of treatment. Endothelial function was significantly improved during atorvastatin treatment, area under the flux versus time curve (AUC)(ACh) was, 538 +/- 362 AU x min before and 682 +/- 276 AU x min after treatment (P=0.042). Plasma NO levels also showed a borderline significant increase from 49 +/- 30 to 57 +/- 37 mu mol/l during the treatment period (P=0.051), though plasma ET-1 (0.37 +/-0.08 vs 0.37 +/-0.12 fmol/ml) and vW (196 +/- 57 vs 197 +/- 37%) were unchanged. Conclusion. Atorvastatin lowered serum cholesterol significantly and improved endothelial function in renal transplant recipients after 4 weeks of treatment. Plasma NO levels were increased during atorvastatin treatment, indicating a possible endothelial protective effect through an 'endothelial-NO pathway'.
引用
收藏
页码:1920 / 1924
页数:5
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